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Fig. 7 | Experimental Hematology & Oncology

Fig. 7

From: Crosstalk between colorectal CSCs and immune cells in tumorigenesis, and strategies for targeting colorectal CSCs

Fig. 7

Colorectal CSCs remodel the immune microenvironment. A DCLK1 expressed by colorectal CSCs activates the ERK signaling pathway and promotes the expression of CXCL1/CXCL2 to recruit myeloid-derived suppressor cells (MDSCs), thereby inhibiting the activity of CD4+ T cells and CD8+ T cells. B Six1 expressed by colorectal CSCs promotes the secretion of CSF-1, CCL2/5 and VEGF and recruits TAMs to form an immunosuppressive microenvironment. IL-4 secreted by colorectal CSCs is an important factor for maintaining TAM tumor-promoting activity

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Experimental Hematology & Oncology

ISSN: 2162-3619

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