Fig. 3

How do bispecific antibodies work. Bispecific antibodies (BsAbs) are engineered to simultaneously bind a cytotoxic cell and a target (a lymphoma cell) to be destroyed. The Fc region binds to cells expressing Fc receptors, like a macrophage, natural killer, or dendritic cell. BsAbs are artificial proteins composed of fragments of two monoclonal antibodies and can bind to two types of antigens (a). BsAbs function by bringing targeted tumor cells close to T-cells to allow killing via perforin and granzyme release (b). ADCC antibody dependent cell-mediated cytotoxicity, FCR Fc receptor, VH heavy chain variable region, VL light chain variable region, TAA tumor associated antigen