Fig. 7From: ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancerHeterogeneity analysis of myeloid cells in primary and lymphatic metastatic TME of PCa. (A). Monocyte distribution subcluster between metastatic and primary lesions using UMAP-2 analysis; (B). Mean percentage of monocyte subclusters in primary and metastatic lesions; (C). Violin plots showing normalized expression levels of marker genes across monocyte subclusters; (D). Metastasis DEGs identified using edgeR package with comparison to primary lesion. Scatter plots showing respective DEG profiles in PCa. Red spots indicate up-regulated genes; green spots indicate no significant change in genes; (E). Functional enrichment analysis for monocyte DEGs; (F). GSEA heatmap of 50 hallmark gene sets in MSigDB database among monocyte subclustersBack to article page