Figure 3

Lovastatin lowers cellular cholesterol and enhances chemo-sensitivity. A) MEC-2 cells were treated with 5 μM lovastatin (L) for 3 days, the samples were extracted and analyzed for total cellular cholesterol (n = 5). C, control (no lovastatin). B) MEC-2 cells were treated with 10 μM fludarabine (F), 10 μg/ml rituximab (R) or their combinations (F + R) in the presence or absence of 5 μM lovastatin for 3 days, and analyzed cell viability by MTT assay (n = 16). The values of lovastatin treatment were statistically different from the controls. *P < 0.05. **P < 0.01.