From: Thalidomide and its analogues in the treatment of Multiple Myeloma
Drug | Route of administration | Dosage | Metabolism/Excretion | Half-life | Dose adjustments |
---|---|---|---|---|---|
Thalidomide | Oral | 50-100 mg | Hepatic/Non-renal | 4-9 hours | None at present |
Lenalidomide (CC-5013) | Oral | 15-25 mg | Renal (67% unchanged) | 3.1-4.5 hours | Adjust for moderate to severe renal impairment |
Pomalidomide (CC-4047) | Oral | 1-5 mg | Renal (67% unchanged) | 6.2-7.9 hours | None at present |